The issue of MSTO aviation-to-rocket is the same issue as rocketry: getting enough lift. It alters the method of lift, but not the fundamental issues of L:W ratios vs gravity (Remembering that Rockets L=T, but aviation L is > T in flat/level flight at/above stall). Blimps have a slight advantage, as they continue to expand with altitude, losing lift slightly slower than fixed wing or rotary wing.
As of yet, only one system uses aviation to rocketry - Scaled Composites/Virgin Galactic. Two generations, soon to be three... As yet, it's only suborbital. It's not more cost effective than Blue Origins' New Shepard, at least not to the consumer. How much of that is profit imperative is undisclosed.
I'll note that only a few currently flying non-Chinese rockets have adequate delta-V to dock to ISS and a crew-rated endorsement: Atlas V, Falcon, Soyuz, LVM3...
Most others are not yet capable of hitting ISS orbit, or are not rated for manned flight. Or both.
As of yet, only one system uses aviation to rocketry - Scaled Composites/Virgin Galactic. Two generations, soon to be three... As yet, it's only suborbital. It's not more cost effective than Blue Origins' New Shepard, at least not to the consumer. How much of that is profit imperative is undisclosed.
I'll note that only a few currently flying non-Chinese rockets have adequate delta-V to dock to ISS and a crew-rated endorsement: Atlas V, Falcon, Soyuz, LVM3...
Most others are not yet capable of hitting ISS orbit, or are not rated for manned flight. Or both.