I've never tried it but always thought it'd be a great campaign. I'd probably run parts of the War of the Quarantine and Abandonment: the PC's would fight a series of savage rearguard actions against Vampires and Vargr as the Regency struggles to evacuate its citizens to the Safe. Lots of pathos as the players are forced to fire on infected refugee ships trying to break the Quarantine. They could even elect to stay on the Wildside as covert operatives keeping taps on encroaching vampires, sadly, never to see their homes again (Codename: Firewall). As a surprise, I might rehabilitate the experimental A.I. aboard the Kininur (you know, the one in Shionthy, where Norris gets his Imperial Stationary from): as an A.I. itself with an organic core, you could say its dynamic enough to anticipate and prevent viral infection and maybe arm it with anit-viral measures itself (SOME programmers have to come up with SOMETHING for Pete's sake: its just a computer virus). That'd make one hell of ship for the players. Maybe give it to them as a treat after facing down the vampires at Catacomb, or something.