Brom: a multi-stage to orbit nuclear atmospheric thermojet (no radioactive release) is probably the cleanest way to go. If given a lifting body for low atm, a hypersonic for the mid-regime, and a release-capsule for trans atmospheric flight, one can attain escape velocity using the ramjet version of thermojet on stage two to hit OV+, and hit the upwards to get there.
Take a lot longer than CT....
Basically, think WhiteKnight/SSOne... but with sealed fusion units for atmospheric work. SSOne is off thrust for almost all of its suborbital flight. Give it a thermo-scramjet, and enough water for minimal thrust maintenance exoatmo, and an intermediate stage which takes it on a thermoram trip to mach 5+ before kickup...
Ports need to be relatively close for economic reasons, and relatively distant for safety reasons, given the traffic flows.
Scott: Remember, in-atmo, one doesn't need more than 0.5G and a clean frame to make multi-mach; it helps, but isn't essential. Given a high efficiency heat source, a thermo-ramjet is free of delta-V limits in atmo. AS the density decreases, top speed increases... as top speed increases, lift is maintained to a lesser degree, but one can get to suborbital velocities in the upper atmosphere on compressed medium alone, if the exhaust and intakes are correct.