Wow....I must be a rare parrot-teacher: I love Enterprise, Farscape
and Firefly.
Welcome, Haplo! I actually have incorporated elements of Firefly into a T20 campaign, although my setting more closely mirrors the first century of U.S. history.
The premise behind MTU is that this region of the 'verse is five years beyond a massive civil war between the the Republic and a number of secessionist systems. The Union won the war and the former rebels were given general amnesty a year or so later, but there is a lot of animosity between members of both sides. In fact, most former secessionists are treated as second-class citizens within the core of the Republic, prompting many of them to flee to the rough frontier.
I use the Aslan to represent the "British" -- a powerful, distant monarchy who formerly ruled the Republic before humanity rebelled and won their freedom a century ago. I also use the Vargr as the Mexicans -- an Old World-style empire that's has lost much of its prestige since losing a major war with the Republic some 25 years ago. "Independent" Vargr corsairs are the main thorn in the Republic's side at the moment. The Sydite are a lower-tech minor power that loosely represent "Aboriginal" elements along the Republic frontier.
The PCs, of course, are former secessionists (although one is an Aslan mercenary), struggling to get by under the perceived oppression of the Republic...and now trying to procure false identities for a physician and his psionic sister, who recently escaped from a Federal facility.
The PCs are at TL 13 (the Republic military is at TL 14)...and I'm about to introduce them to Vargr anarchists.