The case involving the zoo was one in which there was an open environment for the big cats (the Lions and Tigers were potentially able to intermingle) and apparently one of the male Lions took an interest in a female tiger. The zoo staff found out later.
Look up "Liger" on the internet.
Liger is the largest cat that ever lived on Earth (including extinct cats). Even the saber toothed tiger was not that big. Here are 20 amazing liger facts.
ourplnt.com
And Note: Only Male Ligers are infertile (low sperm count); Female Ligers are fertile with both parent species.