As a setting, Aeon rocks - it's hands down the richest setting I have ever seen in an RPG. The front half is a joy to read - it presents this incredibly vibrant, real-feeling world all as soundbites and interviews and news items (there's even one about the latest fads and fashions coming out of Africa).
The only sucky thing about it is the characters... it's just too superheroish for my tastes. But you could easily strip-mine the setting of ideas, or just run it as a more mundane near-future post-cyberpunky thing.
Systemwise IIRC it uses the final or penultimate version of Storyteller that came out before the nWoD (maybe Exalted beat it, I dunno), so it corrects a lot of the flaws in the engine that were in the oWoD (eg the problem where the higher your dice pool, the more likely you are to botch). There is a d20 version but it sucks the soul right out of the game I think, so avoid that.
Have a look around for the hard copy (especially a limited edition one with ring-binding and plastic cover, because that has the original name of the game on it, not "Trinity"), because it's very pretty.
