May I offer something I came to with the Striker system that I'm about to post?
I do away with the concept of weapons-specific damage rolls, other then adding on an HE and/or an energy hit die (and both for plasma/fusion, one could probably do something like that for all the T5 nuanced special damages/weapon types).
Instead, WHERE you hit on the human body counts.
1D is arms, hands, legs.
3D is chest, torso, thigh, spine.
5D is head.
So a dagger plunged through your skull kills as much as a rifle shot.
Pen either pens or it doesn't, if it doesn't you may still have heat/blunt force bruising/hydrostatic shock that is still delivered and so reduced damage applies (but it's not absorbed by armor per se, just not adequately deflected).
An automatic weapon kills due to each bullet doing damage, adds up fast.
You roll one die for hit location/amount of damage, if you like just rule that all autoshots hit the same location. Correlate the weapon pen with armor, adjust if needed, roll the actual damage die, done.
I may or may not also define locations as being associated with STR, DEX and/or END.
Head for instance would be DEX followed by INT/EDU hits.
What I REALLY like about it is you can have an armored chest/torso armor set but exposed arms and head, and it handles that situation. Gets imagery and personal decisions trading off coverage for mobility and encumbrance.
This system is what prompted me to come up with that QND Medical Drama post, the endgame is to merge them so I can describe what is going on with a character hit and subsequent treatment/effects without too many crazy die rolls.