Another way of looking at the question.
Way 1; leads through Solomani Remnants, inhabitants of Ghost, Virus/Aslan fleets and some Joe Dannys fleeing the wave and setting up Rimward.
Way 2; leads along the Vampire highway, through remnants of the factions, scirts the Core and the Black curtain, possability of hearing about the "other" Strephon, Vargr and Vland.
Which has more meat/cool/adventure.
I usually let the players plan the routes themselves and give them potential ups/downs on the situation.
As a GM I personally think Reference then to either forge across the Claw or up through Vland and Corridor is more interesting - there's more stuff players typically want to see. I find players are usually pretty sensible (often overly sensible) and will stay away from the Black Curtain as much as possible. Most players plot a course with the fewest planets and spending their required visits in systems that were considered the Wilds even before 1130, reasoning that since there was less there so less appeal for Vampire Ships (I own Hard Times and Survival Margin, so they were able to plot their courses out that way).
From a practical viewpoint of "realistically" trying to survive a voyage like that, the longer Solomani-Aslan route actually has some things going for it.
* They're in a Victrix-class ship, going through Solomani space has an added appeal: Since Victrix were Solomani ships, if stuff needs repairs, you're more likely to find Victrix-class ships and parts built to Solomani-specifications in their space.
* Both Aslan and Solomani space were lower TL than the old 3I. This that the best Vampire warships they'd meet are TL14, while most likely encounters with Vampires would be TL13, which are TLs more easily handled by the TL12 RC tech.
The disadvantages are hefty, too:
* The trip is just plain longer. More systems to visit, more 1-week jumps, which means more opportunities to encounter Vampires. Lower TL or not, every encounter with a Vampire ship is fraught with mortal danger. Even if their ship survives the fight, it might render their ship incapable of making the trip (my own players have had their original ship shot out from under them and are flying a ship they cobbled together).
* The Aslan and to a lesser extent, the Solomani, were not as devastated as the former 3I in the Rebellion. While the Solomani fought, much of their space wasn't devastated. This means there would have been a lot more intact ships that could possibly become Vampires.