1) Heat dissipation. You cannot throttle or shut down a radiothermal generator (RTG). They have posited a power pack that produces 100+ kilowatts all the time, in use or not. At very least, it's going to be a massive IR source, if not an actual burn hazard to the user.
2) Power pack life and storage. RTGs run constantly, which means that notional 60-day life starts the moment the power pack is fabricated. So you have to ship them from the factory to the front lines in less than a month.
3) Radiological hazards. Polonium is extremely hazardous. Hit one of these power sources with a rifle bullet and you've contaminated a signficant area with prossibly lethal doses of Po-210. (and it doesn't take much; since it's a very potent alpha emitter, any inhalation will be very unhealthy.)
4) Manufacturing. They gloss over the very severe difficulties involved in growing polonium manufacture from micrograms to tons per year. It exists in absurdly small concentrations in nature and building new reactors to breed it seems very unlikely (if it's even possible).