We started off with the Classic "Hard Science" Traveller type game which over time evolved into a more "space opera" type game.
We saw moments of pathos, anger, and High Comedy; One of the players had a psionic who caused a pesky newswoman to disrobe and perform immoral acts upon a member of the party, while in the starport concourse.
An unfortunate occurance is that the rules almost require the players to be in the wrong side of the law. However, that being said play can be rewarding without actual overt lawbreaking. But I must admit that we skated REALLY close to the edge more times than not.
I feel that campaigns should not be deadly serious things, but fun.
I also remember more times than I can count that the prepared adventure went right out the window as the players decided to do something completely different than I had planned. A GM MUST be adaptable.